diff --git a/wp-includes/js/comment-reply.js b/wp-includes/js/comment-reply.js
index a82fc03c87..be54c350d3 100644
--- a/wp-includes/js/comment-reply.js
+++ b/wp-includes/js/comment-reply.js
@@ -95,6 +95,18 @@ window.addComment = ( function( window ) {
 		cancelElement.addEventListener( 'touchstart', cancelEvent );
 		cancelElement.addEventListener( 'click',      cancelEvent );
 
+		// Submit the comment form when the user types CTRL or CMD + 'Enter'.
+		var submitFormHandler = function( e ) {
+			if ( ( e.metaKey || e.ctrlKey ) && e.keyCode === 13 ) {
+				commentFormElement.removeEventListener( 'keydown', submitFormHandler );
+				e.preventDefault();
+				// The submit button ID is 'submit' so we can't call commentFormElement.submit(). Click it instead.
+				commentFormElement.submit.click();
+				return false;
+			}
+		}
+		commentFormElement.addEventListener( 'keydown', submitFormHandler );
+
 		var links = replyLinks( context );
 		var element;
 
diff --git a/wp-includes/js/comment-reply.min.js b/wp-includes/js/comment-reply.min.js
index eedf334d2e..7708a7794e 100644
--- a/wp-includes/js/comment-reply.min.js
+++ b/wp-includes/js/comment-reply.min.js
@@ -1 +1 @@
-window.addComment=function(a){function b(){c(),g()}function c(a){if(t&&(m=j(r.cancelReplyId),n=j(r.commentFormId),m)){m.addEventListener("touchstart",e),m.addEventListener("click",e);for(var b,c=d(a),g=0,h=c.length;g<h;g++)b=c[g],b.addEventListener("touchstart",f),b.addEventListener("click",f)}}function d(a){var b,c=r.commentReplyClass;return a&&a.childNodes||(a=q),b=q.getElementsByClassName?a.getElementsByClassName(c):a.querySelectorAll("."+c)}function e(a){var b=this,c=r.temporaryFormId,d=j(c);d&&o&&(j(r.parentIdFieldId).value="0",d.parentNode.replaceChild(o,d),b.style.display="none",a.preventDefault())}function f(b){var c,d=this,e=i(d,"belowelement"),f=i(d,"commentid"),g=i(d,"respondelement"),h=i(d,"postid");e&&f&&g&&h&&(c=a.addComment.moveForm(e,f,g,h),!1===c&&b.preventDefault())}function g(){if(s){var a={childList:!0,subtree:!0};p=new s(h),p.observe(q.body,a)}}function h(a){for(var b=a.length;b--;)if(a[b].addedNodes.length)return void c()}function i(a,b){return u?a.dataset[b]:a.getAttribute("data-"+b)}function j(a){return q.getElementById(a)}function k(b,c,d,e){var f=j(b);o=j(d);var g,h,i,k=j(r.parentIdFieldId),p=j(r.postIdFieldId);if(f&&o&&k){l(o),e&&p&&(p.value=e),k.value=c,m.style.display="",f.parentNode.insertBefore(o,f.nextSibling),m.onclick=function(){return!1};try{for(var s=0;s<n.elements.length;s++)if(g=n.elements[s],h=!1,"getComputedStyle"in a?i=a.getComputedStyle(g):q.documentElement.currentStyle&&(i=g.currentStyle),(g.offsetWidth<=0&&g.offsetHeight<=0||"hidden"===i.visibility)&&(h=!0),"hidden"!==g.type&&!g.disabled&&!h){g.focus();break}}catch(t){}return!1}}function l(a){var b=r.temporaryFormId,c=j(b);c||(c=q.createElement("div"),c.id=b,c.style.display="none",a.parentNode.insertBefore(c,a))}var m,n,o,p,q=a.document,r={commentReplyClass:"comment-reply-link",cancelReplyId:"cancel-comment-reply-link",commentFormId:"commentform",temporaryFormId:"wp-temp-form-div",parentIdFieldId:"comment_parent",postIdFieldId:"comment_post_ID"},s=a.MutationObserver||a.WebKitMutationObserver||a.MozMutationObserver,t="querySelector"in q&&"addEventListener"in a,u=!!q.documentElement.dataset;return t&&"loading"!==q.readyState?b():t&&a.addEventListener("DOMContentLoaded",b,!1),{init:c,moveForm:k}}(window);
\ No newline at end of file
+window.addComment=function(a){function b(){c(),g()}function c(a){if(t&&(m=j(r.cancelReplyId),n=j(r.commentFormId),m)){m.addEventListener("touchstart",e),m.addEventListener("click",e);var b=function(a){if((a.metaKey||a.ctrlKey)&&13===a.keyCode)return n.removeEventListener("keydown",b),a.preventDefault(),n.submit.click(),!1};n.addEventListener("keydown",b);for(var c,g=d(a),h=0,i=g.length;h<i;h++)c=g[h],c.addEventListener("touchstart",f),c.addEventListener("click",f)}}function d(a){var b,c=r.commentReplyClass;return a&&a.childNodes||(a=q),b=q.getElementsByClassName?a.getElementsByClassName(c):a.querySelectorAll("."+c)}function e(a){var b=this,c=r.temporaryFormId,d=j(c);d&&o&&(j(r.parentIdFieldId).value="0",d.parentNode.replaceChild(o,d),b.style.display="none",a.preventDefault())}function f(b){var c,d=this,e=i(d,"belowelement"),f=i(d,"commentid"),g=i(d,"respondelement"),h=i(d,"postid");e&&f&&g&&h&&(c=a.addComment.moveForm(e,f,g,h),!1===c&&b.preventDefault())}function g(){if(s){var a={childList:!0,subtree:!0};p=new s(h),p.observe(q.body,a)}}function h(a){for(var b=a.length;b--;)if(a[b].addedNodes.length)return void c()}function i(a,b){return u?a.dataset[b]:a.getAttribute("data-"+b)}function j(a){return q.getElementById(a)}function k(b,c,d,e){var f=j(b);o=j(d);var g,h,i,k=j(r.parentIdFieldId),p=j(r.postIdFieldId);if(f&&o&&k){l(o),e&&p&&(p.value=e),k.value=c,m.style.display="",f.parentNode.insertBefore(o,f.nextSibling),m.onclick=function(){return!1};try{for(var s=0;s<n.elements.length;s++)if(g=n.elements[s],h=!1,"getComputedStyle"in a?i=a.getComputedStyle(g):q.documentElement.currentStyle&&(i=g.currentStyle),(g.offsetWidth<=0&&g.offsetHeight<=0||"hidden"===i.visibility)&&(h=!0),"hidden"!==g.type&&!g.disabled&&!h){g.focus();break}}catch(t){}return!1}}function l(a){var b=r.temporaryFormId,c=j(b);c||(c=q.createElement("div"),c.id=b,c.style.display="none",a.parentNode.insertBefore(c,a))}var m,n,o,p,q=a.document,r={commentReplyClass:"comment-reply-link",cancelReplyId:"cancel-comment-reply-link",commentFormId:"commentform",temporaryFormId:"wp-temp-form-div",parentIdFieldId:"comment_parent",postIdFieldId:"comment_post_ID"},s=a.MutationObserver||a.WebKitMutationObserver||a.MozMutationObserver,t="querySelector"in q&&"addEventListener"in a,u=!!q.documentElement.dataset;return t&&"loading"!==q.readyState?b():t&&a.addEventListener("DOMContentLoaded",b,!1),{init:c,moveForm:k}}(window);
\ No newline at end of file
diff --git a/wp-includes/version.php b/wp-includes/version.php
index 239331c30f..57e772b1af 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -13,7 +13,7 @@
  *
  * @global string $wp_version
  */
-$wp_version = '5.3-alpha-45789';
+$wp_version = '5.3-alpha-45790';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.